Alzheimer's and Lyme Disease References

1: Neuroreport. 1993 Jul;4(7):841-8. Links
Comment in:
Neuroreport. 1993 Jul;4(7):840.
Alzheimer's disease--a spirochetosis? (Dr.Miklossy post mortems 14 out of 14 brains)
Miklossy J.
Division of Neuropathology, University of Lausanne, Switzerland.

The aetiology of Alzheimer's disease (AD), which affects a large proportion of the aged population is unknown and the treatment unresolved. The role of
beta amyloid protein (beta A4), derived from a larger amyloid precursor protein (APP) in AD is the subject of intense research. Here I report observations that in 14 autopsy cases with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue. Thirteen age-matched control cases were without spirochetes. Reference strains of spirochetes and those isolated from brains of AD patients, showed positive immunoreaction with monoclonal antibody against the beta amyloid precursor protein. These observations suggest that spirochetes may be one of the causes of AD and that they may be the source of the beta amyloid deposited in the AD brain.

PMID: 8369471 [PubMed - indexed for MEDLINE

1: Neuroreport. 1994 Jun 2;5(10):1201-4. Links
Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimer's disease.
Miklossy J, Kasas S, Janzer RC, Ardizzoni F, Van der Loos H. University Institute of Pathology, Division of Neuropathology, Lausanne,
Switzerland.

Recently it was reported that, at autopsy, in neuropathologically confirmed cases of Alzheimer's disease spirochaetes were found in blood and cerebrospinal fluid using dark-field microscopy. Moreover, the spirochaetes were isolated and cultured from brain tissue. We now show, using scanning electron microscopy and atomic force microscopy that the helically shaped microorganisms isolated and cultured from the Alzheimer brains possess axial filaments. This indicates that these microorganisms taxonomically indeed belong to the order Spirochaetales. A morphometric analysis reinforces this notion.

PMID: 7919164 [PubMed - indexed for MEDLINE]

Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Related Articles, Links 

Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease.
J Alzheimers Dis. 2004 Dec;6(6):639-49; discussion 673-81. PMID: 15665404 [PubMed - indexed for MEDLINE]
 

2:  Kuntzer T, Bogousslavsky J, Miklossy J, Steck AJ, Janzer R, Regli F.
Related Articles, Links  Borrelia rhombencephalomyelopathy.
Arch Neurol. 1991 Aug;48(8):832-6.
PMID: 1898257 [PubMed - indexed for MEDLINE]

3:  Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Related Articles, Links 
Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary
neurosyphilis.
Acta Neuropathol (Berl). 1990;80(5):568-72.
PMID: 2251916 [PubMed - indexed for MEDLINE]


 

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